Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 2/20 | 0.35 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL743402 | 0.71 | MAPK1 (0.39) | ALDH1A1MAPTMAPK1HSD17B10SMN1; SMN2 | |
| SCHEMBL3233311 | 0.69 | HTR2C (0.42) | PIP4K2APIP4K2CTP53NPC1ALDH1A1 | |
| SCHEMBL5336326 | 0.69 | PIP4K2A (0.37) | PIP4K2APIP4K2CTP53NPC1ALDH1A1 | |
| SCHEMBL11202541 | 0.69 | ADORA2A (0.47) | PIP4K2APIP4K2CTP53NPC1ALDH1A1 | |
| SCHEMBL29994236 | 0.67 | NTRK1 (0.41) | ALDH1A1HSD17B10KDM4ENTRK1LTK | |
| SCHEMBL857548 | 0.67 | CLK4 (0.33) | ALDH1A1SMN1; SMN2KDM4ENTRK1LTK | |
| SCHEMBL5463111 | 0.67 | NTRK1 (0.33) | NTRK1LTKTYRO3NTRK2CLK4 | |
| SCHEMBL1160659 | 0.67 | NTRK1 (0.41) | ALDH1A1HSD17B10KDM4ENTRK1LTK | |
| SCHEMBL18671569 | 0.67 | NTRK1 (0.33) | NTRK1LTKTYRO3NTRK2CLK4 | |
| SCHEMBL24175622 | 0.67 | NTRK1 (0.34) | HTTNTRK1LTKTYRO3NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8247409-B2 | Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use | AMGEN INC. (US) | 2012-08-21 | — | — | US | disclosed |
| US-7745449-B2 | Thieno-[2,3-d]pyrimidine and thieno-pyridazine compounds and methods of use | AMGEN INC. (US) | 2010-06-29 | — | — | US | disclosed |
| US-20100125074-A1 | Thieno-[2,3-d]Pyrimidine and Thieno-Pyridazine Compounds and Methods of Use | AMGEN INC. (US) | 2010-05-20 | — | — | US | disclosed |
| EP-2038289-A2 | THIENO-[2,3-D]PYRIMIDINE AND THIENO-PYRIDAZINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| US-7449472-B2 | Methods of inhibiting p38 with substituted bicyclic pyrimidines | ROCHE PALO ALTO LLC (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449472-B2 | Methods of inhibiting p38 with substituted bicyclic pyrimidines | ROCHE PALO ALTO LLC (US) | 2008-11-11 | — | — | US | disclosed |
| US-7449472-B2 | Methods of inhibiting p38 with substituted bicyclic pyrimidines | ROCHE PALO ALTO LLC (US) | 2008-11-11 | — | — | US | disclosed |
| US-7439247-B2 | Bicyclic pyridine and pyrimidine P38 kinase inhibitors | ROCHE PALO ALTOP LLC (US) | 2008-10-21 | — | — | US | disclosed |
| US-7439247-B2 | Bicyclic pyridine and pyrimidine P38 kinase inhibitors | ROCHE PALO ALTOP LLC (US) | 2008-10-21 | — | — | US | disclosed |
| US-7439247-B2 | Bicyclic pyridine and pyrimidine P38 kinase inhibitors | ROCHE PALO ALTOP LLC (US) | 2008-10-21 | — | — | US | disclosed |
| WO-2007124181-A2 | THIENO-[2,3-D]PYRIMIDINE AND THIENO-PYRIDAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2007-11-01 | — | — | WO | disclosed |
| US-7091347-B2 | Bicyclic pyridine and pyrimidine p38 kinase inhibitors | ROCHE PALO ALTO LLC (US) | 2006-08-15 | — | — | US | disclosed |
| US-20060084803-A1 | Bicyclic pyridine and pyrimidine P38 kinase inhibitors | CHEN JIAN J | 2006-04-20 | — | — | US | disclosed |
| US-20050288312-A1 | Bicyclic pyridine and pyrimidine p38 kinase inhibitors | CHEN JIAN J | 2005-12-29 | — | — | US | disclosed |
| CN-1639168-A | Bicyclic pyridine and pyrimidine P38 kinase inhibitors | HOFFMANN LA ROCHE (CH) | 2005-07-13 | — | — | CN | disclosed |
| EP-1537112-A1 | CONDENSED PYRIDINES AND PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | Astrazeneca AB (SE) | 2005-06-08 | — | — | EP | disclosed |
| EP-1485390-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE P38 KINASE INHIBITORS | F. Hoffman-la Roche AG (CH) | 2004-12-15 | — | — | EP | disclosed |
| WO-2004013141-A1 | CONDENSED PYRIDINES AND PYRIMIDINES WITH TIE2 (TEK) ACTIVITY | ASTRAZENECA AB (SE) | 2004-02-12 | — | — | WO | disclosed |
| US-20030207900-A1 | Bicyclic pyridine and pyrimidine p38 kinase inhibitors | ROCHE PALO ALTO LLC | 2003-11-06 | — | — | US | disclosed |
| WO-2003074530-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE P38 KINASE INHIBITORS | F. HOFFMAN-LA ROCHE AG (CH) | 2003-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288312-A1 | Bicyclic pyridine and pyrimidine p38 kinase inhibitors | MAPK1, MAP3K1, MAP3K8 | PIP4K2A 314/4885PIP4K2C 333/4885TP53 1270/4885 |
| US-20100125074-A1 | Thieno-[2,3-d]Pyrimidine and Thieno-Pyridazine Compounds and Methods of Use | CDK2, TBXA2R, TBXAS1 | PIP4K2A 160/4885PIP4K2C 187/4885TP53 1853/4885 |
| US-20030207900-A1 | Bicyclic pyridine and pyrimidine p38 kinase inhibitors | MAPK1, MAP3K1, MAPKAPK2 | PIP4K2A 293/4885PIP4K2C 301/4885TP53 1298/4885 |
| US-20060084803-A1 | Bicyclic pyridine and pyrimidine P38 kinase inhibitors | MAPK1, MAP3K1, MAP3K8 | PIP4K2A 314/4885PIP4K2C 333/4885TP53 1270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.