SCHEMBL3228076

SCHEMBL3228076

Nc1cc(F)ccc1NC(=O)CCCCCC(=O)Nc1nc(-c2ccc(N3CCOCC3)cc2)cs1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 8/20 0.55
HDAC1 Q13547 10/20 0.55
HDAC6 Q9UBN7 6/20 0.55
HDAC9 Q9UKV0 5/20 0.55
LMNA P02545 2/20 0.52
MAPK1 P28482 1/20 0.52
HDAC2 Q92769 5/20 0.51
HDAC10 Q969S8 5/20 0.51
NCOR2 Q9Y618 2/20 0.51
MMP2 P08253 1/20 0.51
MMP8 P22894 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.49
CYP1A1 P04798 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP1B1 Q16678 1/20 0.49
MAOA P21397 1/20 0.48
MAOB P27338 1/20 0.48
KMT2A Q03164 1/20 0.48
POLB P06746 1/20 0.46
HDAC8 Q9BY41 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3235296 0.88 HDAC1 (0.70) HDAC3HDAC1HDAC6HDAC9LMNA
SCHEMBL3228071 0.85 HDAC1 (0.47) HDAC3HDAC1HDAC6HDAC9LMNA
SCHEMBL3238723 0.84 HDAC1 (0.61) HDAC3HDAC1HDAC6HDAC9LMNA
SCHEMBL3235100 0.82 HDAC3 (0.62) HDAC3HDAC1HDAC2HDAC10NCOR2
SCHEMBL3241203 0.82 HDAC1 (0.64) HDAC3HDAC1HDAC6HDAC9LMNA
SCHEMBL22500344 0.80 KMT2A (0.58) HDAC3HDAC1HDAC6HDAC9LMNA
SCHEMBL3238457 0.76 HDAC1 (0.56) HDAC3HDAC1HDAC6HDAC9HDAC2
SCHEMBL22501268 0.76 KMT2A (0.62) LMNAMAPK1MMP2MMP8SMN1; SMN2
SCHEMBL3262051 0.75 CYP1A2 (0.43) LMNAMAPK1SMN1; SMN2CYP1A1CYP1A2
SCHEMBL3235298 0.75 HDAC1 (0.54) HDAC3HDAC1HDAC6HDAC9LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010028193-A1 COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS REPLIGEN CORPORATION (US) 2010-03-11 WO claimed
WO-2010028193-A1 COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS REPLIGEN CORPORATION (US) 2010-03-11 WO disclosed