Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 14/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 12/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3262614 | 0.91 | HDAC3 (0.50) | HDAC3HDAC1HDAC2HDAC10NCOR2 | |
| SCHEMBL3235298 | 0.83 | HDAC1 (0.54) | HDAC3HDAC1HDAC2HDAC10NCOR2 | |
| SCHEMBL3228076 | 0.82 | HDAC3 (0.55) | HDAC3HDAC1HDAC2HDAC10NCOR2 | |
| SCHEMBL7933437 | 0.81 | POLB (0.50) | HDAC3HDAC1HDAC2HDAC10SMN1; SMN2 | |
| SCHEMBL3238457 | 0.78 | HDAC1 (0.56) | HDAC3HDAC1HDAC2HDAC10NCOR2 | |
| SCHEMBL1937893 | 0.77 | HDAC3 (1.00) | HDAC3HDAC1NCOR2 | |
| SCHEMBL3237865 | 0.77 | HDAC3 (0.53) | HDAC3HDAC1HDAC2HDAC10NCOR2 | |
| SCHEMBL3235296 | 0.77 | HDAC1 (0.70) | HDAC3HDAC1HDAC2HDAC10NCOR2 | |
| SCHEMBL3238723 | 0.75 | HDAC1 (0.61) | HDAC3HDAC1HDAC2HDAC10NCOR2 | |
| SCHEMBL7929398 | 0.74 | HDAC1 (0.74) | HDAC3HDAC1HDAC2HDAC10NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | claimed |
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |