Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 5/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.47 |
| ▸ | NAMPT | P43490 | 4/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3242068 | 0.99 | GABRG2 (0.48) | GABRG2GABRB3GABRA5NAMPTKEAP1 | |
| SCHEMBL3233919 | 0.97 | GABRG2 (0.46) | GABRG2GABRB3GABRA5NAMPTKEAP1 | |
| SCHEMBL1041527 | 0.89 | HRH3 (0.40) | NAMPTKCNH2HRH3HSP90AA1 | |
| SCHEMBL988477 | 0.89 | HRH3 (0.41) | GABRG2GABRB3GABRA5KCNH2HRH3 | |
| SCHEMBL3238202 | 0.88 | HRH3 (0.44) | GABRG2GABRB3GABRA5NAMPTKCNH2 | |
| SCHEMBL3265311 | 0.86 | HRH3 (0.46) | GABRG2GABRB3GABRA5KCNH2HRH3 | |
| SCHEMBL3233867 | 0.86 | HRH3 (0.42) | HRH3 | |
| SCHEMBL3233498 | 0.85 | HRH3 (0.47) | GABRG2GABRB3GABRA5NAMPTKCNH2 | |
| SCHEMBL3237639 | 0.85 | GABRG2 (0.46) | GABRG2GABRB3GABRA5KCNH2HRH3 | |
| SCHEMBL3262190 | 0.85 | ESR1 (0.41) | GABRG2GABRB3GABRA5KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010026113-A1 | ACYL- AND SUFONYL TETRAHYDRONAPHTHYRIDINES AND AZA DERIVATIVES THEREOF AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-03-11 | — | — | WO | claimed |
| WO-2010026113-A1 | ACYL- AND SUFONYL TETRAHYDRONAPHTHYRIDINES AND AZA DERIVATIVES THEREOF AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010026113-A1 | ACYL- AND SUFONYL TETRAHYDRONAPHTHYRIDINES AND AZA DERIVATIVES THEREOF AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-03-11 | — | — | WO | disclosed |