Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.41 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988477 | 0.88 | HRH3 (0.41) | HRH3DRD3GABRG2GABRB3GABRA5 | |
| SCHEMBL3238202 | 0.87 | HRH3 (0.44) | HRH3DRD3GABRG2GABRB3GABRA5 | |
| SCHEMBL3242068 | 0.86 | GABRG2 (0.48) | HRH3GABRG2GABRB3GABRA5KCNH2 | |
| SCHEMBL3233919 | 0.86 | GABRG2 (0.46) | HRH3DRD3GABRG2GABRB3GABRA5 | |
| SCHEMBL1041527 | 0.85 | HRH3 (0.40) | HRH3DRD3KCNH2CYP2D6 | |
| SCHEMBL3233867 | 0.85 | HRH3 (0.42) | HRH3DRD3CYP2D6 | |
| SCHEMBL3265311 | 0.85 | HRH3 (0.46) | HRH3GABRG2GABRB3GABRA5KCNH2 | |
| SCHEMBL3228416 | 0.85 | GABRG2 (0.47) | HRH3GABRG2GABRB3GABRA5KCNH2 | |
| SCHEMBL1041601 | 0.84 | HRH3 (0.48) | ESR2HRH3DRD3CYP2D6 | |
| SCHEMBL3237639 | 0.84 | GABRG2 (0.46) | HRH3DRD3GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010026113-A1 | ACYL- AND SUFONYL TETRAHYDRONAPHTHYRIDINES AND AZA DERIVATIVES THEREOF AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-03-11 | — | — | WO | claimed |
| WO-2010026113-A1 | ACYL- AND SUFONYL TETRAHYDRONAPHTHYRIDINES AND AZA DERIVATIVES THEREOF AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010026113-A1 | ACYL- AND SUFONYL TETRAHYDRONAPHTHYRIDINES AND AZA DERIVATIVES THEREOF AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-03-11 | — | — | WO | disclosed |