SCHEMBL3228713

SCHEMBL3228713

CC1CC(=O)C(C(=O)O)C(C)(c2ccc(F)c(F)c2)C1

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CCR2 P41597 9/20 0.49
HCAR3 P49019 1/20 0.40
HCAR2 Q8TDS4 1/20 0.40
CHRNA1 P02708 1/20 0.37
CHRNG P07510 1/20 0.37
CHRNB1 P11230 1/20 0.37
CHRNB2 P17787 1/20 0.37
SLC6A2 P23975 1/20 0.37
CHRNB4 P30926 1/20 0.37
CHRNA3 P32297 1/20 0.37
CHRNA4 P43681 1/20 0.37
SLC6A3 Q01959 1/20 0.37
CHRND Q07001 1/20 0.37
TSHR P16473 1/20 0.35
AKR1C3 P42330 1/20 0.32
AKR1C2 P52895 1/20 0.32
AKR1C1 Q04828 1/20 0.32
MC4R P32245 5/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1779233 0.83 CCR2 (0.41) CCR2HCAR3HCAR2CHRNA1CHRNG
SCHEMBL3235269 0.82 CCR2 (0.40) CCR2
SCHEMBL3220089 0.82 CCR2 (0.49) CCR2CHRNA1CHRNGCHRNB1CHRNB2
SCHEMBL1833463 0.79 CCR2 (0.50) CCR2CHRNA1CHRNGCHRNB1CHRNB2
SCHEMBL31381601 0.75 CCR2 (0.51) CCR2HCAR3HCAR2CHRNA1CHRNG
SCHEMBL3233210 0.74 CCR2 (0.49) CCR2HCAR3HCAR2CHRNA1CHRNG
SCHEMBL1779234 0.71 CCR2 (0.46) CCR2HCAR3HCAR2CHRNA1CHRNG
SCHEMBL17525667 0.70 CCR2 (0.48) CCR2HCAR3HCAR2CHRNA1CHRNG
SCHEMBL1779888 0.70 MEN1 (0.37) CCR2
SCHEMBL1778995 0.69 CCR2 (0.44) CCR2CHRNA1CHRNGCHRNB1CHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8507559-B2 Cyclohexenyl modulators of chemokine receptor activity BRISTOL-MYERS SQUIBB COMPANY (US) 2013-08-13 US disclosed
EP-2318352-B1 CYCLOHEXENYL COMPOUNDS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL MYERS SQUIBB CO (US) 2012-12-19 EP disclosed
WO-2010009068-A2 CYCLOHEXENYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2010-01-21 WO disclosed