SCHEMBL1833463

SCHEMBL1833463

CC1CC(=O)C(C(=O)O)C(C)(c2cccc(-c3ccccc3)c2)C1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR2 P41597 5/20 0.50
SLC6A2 P23975 2/20 0.40
SLC6A4 P31645 2/20 0.40
SLC6A3 Q01959 2/20 0.40
EDNRB P24530 2/20 0.34
EDNRA P25101 2/20 0.34
BRD4 O60885 3/20 0.34
CREBBP Q92793 2/20 0.34
HSD11B1 P28845 1/20 0.34
BACE1 P56817 1/20 0.33
OPRM1 P35372 3/20 0.33
OPRK1 P41145 2/20 0.33
OPRD1 P41143 2/20 0.33
CHRNA1 P02708 1/20 0.32
CHRNG P07510 1/20 0.32
CHRNB1 P11230 1/20 0.32
CHRNB2 P17787 1/20 0.32
CHRNB4 P30926 1/20 0.32
CHRNA3 P32297 1/20 0.32
CHRNA4 P43681 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1783197 0.88 CCR2 (0.46) CCR2SLC6A2SLC6A4SLC6A3BRD4
SCHEMBL3220089 0.79 CCR2 (0.49) CCR2SLC6A2SLC6A4SLC6A3CHRNA1
SCHEMBL3228713 0.79 CCR2 (0.49) CCR2SLC6A2SLC6A3CHRNA1CHRNG
SCHEMBL3237823 0.75 CCR2 (0.50) CCR2SLC6A2SLC6A4SLC6A3OPRM1
SCHEMBL1780501 0.70 CCR2 (0.47) CCR2SLC6A2SLC6A4SLC6A3OPRM1
Bicarbonate SCHEMBL14237231 0.67 CCR2 (0.58) CCR2SLC6A2SLC6A4SLC6A3CHRNA1
SCHEMBL1780947 0.67 CCR2 (1.00) CCR2
SCHEMBL1780502 0.65 CCR2 (0.50) CCR2SLC6A2SLC6A4SLC6A3HSD11B1
SCHEMBL1779888 0.64 MEN1 (0.37) CCR2
SCHEMBL23356985 0.60 LMNA (0.49) CCR2HSD11B1OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8507559-B2 Cyclohexenyl modulators of chemokine receptor activity BRISTOL-MYERS SQUIBB COMPANY (US) 2013-08-13 US disclosed
EP-2318352-B1 CYCLOHEXENYL COMPOUNDS AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL MYERS SQUIBB CO (US) 2012-12-19 EP disclosed
EP-2318352-A2 CYCLOHEXENYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Bristol-Myers Squibb Company (US) 2011-05-11 EP disclosed
WO-2010009068-A2 CYCLOHEXENYL MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2010-01-21 WO disclosed