Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MPI | P34949 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11493109 | 0.95 | ALDH1A1 (0.50) | ALDH1A1KDM4EL3MBTL1ALOX12NPSR1 | |
| SCHEMBL16572388 | 0.83 | ALDH1A1 (0.68) | ALDH1A1KDM4EL3MBTL1GFERKMT2A | |
| SCHEMBL5510459 | 0.83 | ALDH1A1 (0.68) | ALDH1A1KDM4EL3MBTL1GFERKMT2A | |
| SCHEMBL4060240 | 0.81 | ALDH1A1 (0.47) | ALDH1A1KDM4EL3MBTL1ALOX12NPSR1 | |
| SCHEMBL11489064 | 0.81 | ALDH1A1 (0.56) | ALDH1A1KDM4EL3MBTL1GFERKMT2A | |
| SCHEMBL11493352 | 0.80 | ALDH1A1 (0.46) | ALDH1A1TSHRKMT2ALMNAMAPT | |
| SCHEMBL2947238 | 0.80 | TSHR (0.50) | ALDH1A1KDM4EL3MBTL1ALOX12NPSR1 | |
| SCHEMBL2950084 | 0.80 | KDM4E (0.71) | ALDH1A1KDM4EL3MBTL1ALOX12NPSR1 | |
| SCHEMBL2947236 | 0.80 | TSHR (0.50) | ALDH1A1KDM4EL3MBTL1ALOX12NPSR1 | |
| SCHEMBL27775260 | 0.80 | TSHR (0.50) | ALDH1A1KDM4EL3MBTL1ALOX12NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010189-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |