Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 3/20 | 1.00 |
| ▸ | THRB | P10828 | 3/20 | 1.00 |
| ▸ | KDM5A | P29375 | 7/20 | 0.77 |
| ▸ | KDM4A | O75164 | 3/20 | 0.77 |
| ▸ | ING2 | Q9H160 | 1/20 | 0.77 |
| ▸ | SIRT3 | Q9NTG7 | 9/20 | 0.74 |
| ▸ | EYA3 | Q99504 | 1/20 | 0.73 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.73 |
| ▸ | KDM7A | Q6ZMT4 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.73 |
| ▸ | TP53 | P04637 | 2/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.73 |
| ▸ | MLNR | O43193 | 1/20 | 0.73 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.73 |
| ▸ | PHF2 | O75151 | 1/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.73 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.73 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19895688 | 0.91 | THRA (0.83) | THRATHRBKDM5AKDM4AING2 | |
| SCHEMBL9165920 | 0.90 | THRA (0.82) | THRATHRBKDM5AKDM4AING2 | |
| SCHEMBL25873319 | 0.90 | KDM5A (0.86) | THRATHRBKDM5AKDM4AING2 | |
| SCHEMBL23717920 | 0.89 | THRA (0.81) | THRATHRBKDM5AKDM4AING2 | |
| SCHEMBL19895690 | 0.89 | KDM5A (0.85) | THRATHRBKDM5AKDM4AING2 | |
| SCHEMBL7860433 | 0.88 | ABCB1 (0.85) | THRATHRBKDM5AKDM4AING2 | |
| SCHEMBL6336963 | 0.88 | THRA (0.78) | THRATHRBKDM5AKDM4AING2 | |
| SCHEMBL8625157 | 0.87 | THRA (0.77) | THRATHRBKDM5AKDM4AING2 | |
| SCHEMBL7242769 | 0.87 | KDM5A (1.00) | THRATHRBKDM5AKDM4AING2 | |
| SCHEMBL10670973 | 0.87 | SIRT3 (0.82) | THRATHRBKDM5AKDM4AING2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040234592-A1 | Mixture containing thyroid hormone , ethanolamine and emulsifier | KARO BIO AB (SE) | 2004-11-25 | — | — | US | claimed |
| EP-1404413-A2 | DERMATOLOGICAL FORMULATIONS | KARO BIO AB (SE) | 2004-04-07 | — | — | EP | claimed |
| EP-1398024-A2 | Uses for thyroid hormone compounds | KARO BIO AB (SE) | 2004-03-17 | — | — | EP | claimed |
| EP-0831769-B1 | NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS | KAROBIO AB (SE) | 2003-10-15 | — | — | EP | claimed |
| EP-1328265-A2 | NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS | KARO BIO AB (SE) | 2003-07-23 | — | — | EP | claimed |
| WO-2002089917-A2 | DERMATOLOGICAL FORMULATIONS | KARO BIO AB (SE) | 2002-11-14 | — | — | WO | claimed |
| US-20020123521-A1 | Treatment for dermal skin atrophy using thyroid hormone compounds or thyroid hormone-like compounds | KOO, CATHERINE, DR | 2002-09-05 | — | — | US | claimed |
| US-6380255-B1 | TOPICALLY APPLYING TO SKIN THYROID HORMONE COMPOUND TOGETHER WITH A BASE FOR THERAPY OF SKIN ATROPHY | KARO BIO AB (SE) | 2002-04-30 | — | — | US | claimed |
| WO-2002005834-A2 | NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE AGONIST COMPOUNDS FOR TREATING DERMIS CONDITIONS | KARO BIO AB (SE) | 2002-01-24 | — | — | WO | claimed |
| US-6221911-B1 | REDUCING SUBCUTANEOUS FAT DEPOSITS IN A SUBJECT; IMPROVING THE SKIN CONDITION OF A SUBJECT | KARO BIO AB (SE) | 2001-04-24 | — | — | US | claimed |
| EP-0831769-A2 | NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS | KARO BIO AB (SE) | 1998-04-01 | — | — | EP | claimed |
| WO-1996040048-A9 | NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS | — | 1997-03-27 | — | — | WO | claimed |
| WO-1996040048-A2 | NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS | KARO BIO AB (SE) | 1996-12-19 | — | — | WO | claimed |
| US-5567728-A | BENZOYL BENZOFURAN DERIVATIVES USED TO PREVENT OR TREAT CARDIAC ARRHYTHMIA | KAROBIO AKTIEBOLAG (SE) | 1996-10-22 | — | — | US | claimed |
| EP-0584186-B1 | RECEPTOR LIGANDS | KAROBIO AB (SE) | 1996-08-21 | — | — | EP | claimed |
| EP-0584186-A1 | RECEPTOR LIGANDS. | KAROBIO AB (SE) | 1994-03-02 | — | — | EP | claimed |
| WO-1992020331-A1 | RECEPTOR LIGANDS | KAROBIO AKTIEBOLAG (SE) | 1992-11-26 | — | — | WO | claimed |
| US-20100047332-A1 | Treatments for burns using thyroid hormone compound in a human | KOO, CATHERINE, DR | 2010-02-25 | — | — | US | disclosed |
| WO-1992020331-A1 | RECEPTOR LIGANDS | KAROBIO AKTIEBOLAG (SE) | 1992-11-26 | — | — | WO | disclosed |
| WO-1992020331-A1 | RECEPTOR LIGANDS | KAROBIO AKTIEBOLAG (SE) | 1992-11-26 | — | — | WO | disclosed |