Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 16/20 | 0.55 |
| ▸ | PIM2 | Q9P1W9 | 16/20 | 0.55 |
| ▸ | CSF1R | P07333 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | KIT | P10721 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3232275 | 1.00 | PIM1 (0.55) | PIM1PIM2CSF1RKDRFLT3 | |
| SCHEMBL3229096 | 1.00 | PIM1 (0.55) | PIM1PIM2CSF1RKDRFLT3 | |
| SCHEMBL3229091 | 1.00 | PIM1 (0.55) | PIM1PIM2CSF1RKDRFLT3 | |
| SCHEMBL3232268 | 1.00 | PIM1 (0.55) | PIM1PIM2CSF1RKDRFLT3 | |
| Hydrochloric Acid SCHEMBL731464 | 0.99 | PIM1 (0.54) | PIM1PIM2CSF1RKDRFLT3 | |
| Hydrochloric Acid SCHEMBL731465 | 0.99 | PIM1 (0.54) | PIM1PIM2CSF1RKDRFLT3 | |
| Hydrochloric Acid SCHEMBL731463 | 0.99 | PIM1 (0.54) | PIM1PIM2CSF1RKDRFLT3 | |
| SCHEMBL3718465 | 0.81 | HTR1A (0.53) | PIM1PIM2DDB1CRBN | |
| SCHEMBL3717239 | 0.81 | HTR1A (0.53) | PIM1PIM2DDB1CRBN | |
| SCHEMBL1115666 | 0.81 | HTR1A (0.53) | PIM1PIM2DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022076-A1 | TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2010-02-25 | — | — | WO | disclosed |