Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.53 |
| ▸ | PIM1 | P11309 | 4/20 | 0.53 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.53 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1115666 | 1.00 | HTR1A (0.53) | HTR1ASLC6A2PIM1PIM2DDB1 | |
| SCHEMBL3718465 | 1.00 | HTR1A (0.53) | HTR1ASLC6A2PIM1PIM2DDB1 | |
| SCHEMBL3715640 | 0.91 | DDB1 (0.53) | HTR1ASLC6A2PIM1PIM2DDB1 | |
| SCHEMBL21227882 | 0.88 | DDB1 (0.52) | HTR1ASLC6A2DDB1CRBNKDM4E | |
| Hydrochloric Acid SCHEMBL21222507 | 0.87 | DDB1 (0.51) | HTR1ASLC6A2DDB1CRBNKDM4E | |
| SCHEMBL29506919 | 0.83 | DDB1 (0.56) | DDB1CRBNKDM4E | |
| SCHEMBL13137148 | 0.83 | CHRNB2 (0.45) | HTR1ASLC6A2PIM1PIM2CHRNB2 | |
| SCHEMBL3229084 | 0.81 | PIM1 (0.55) | PIM1PIM2DDB1CRBN | |
| SCHEMBL3232275 | 0.81 | PIM1 (0.55) | PIM1PIM2DDB1CRBN | |
| SCHEMBL3232268 | 0.81 | PIM1 (0.55) | PIM1PIM2DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010094643-A1 | QUINOLINE DERIVATIVES AND THEIR USES FOR RHINITIS AND URTICARIA | GLAXO GROUP LIMITED (GB) | 2010-08-26 | — | — | WO | disclosed |