Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 10/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL322982 | 0.74 | HSD11B1 (0.42) | HSD11B1TSHRPTGS1PTGS2ALDH1A1 | |
| SCHEMBL6600300 | 0.74 | HSD11B1 (0.42) | HSD11B1TSHRPTGS1PTGS2ALDH1A1 | |
| SCHEMBL1500290 | 0.74 | TSHR (0.58) | HSD11B1TSHRPTGS1PTGS2ALDH1A1 | |
| SCHEMBL3562652 | 0.74 | ALDH1A1 (0.43) | HSD11B1TSHRPTGS1PTGS2ALDH1A1 | |
| SCHEMBL544019 | 0.74 | SMN1; SMN2 (0.50) | HSD11B1TSHRKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL618031 | 0.74 | HSD11B1 (0.46) | HSD11B1TSHRPTGS1PTGS2ALDH1A1 | |
| SCHEMBL1395472 | 0.72 | TSHR (0.70) | TSHRMAPK9MAPK10PTGS1PTGS2 | |
| SCHEMBL11846648 | 0.72 | HSD11B1 (0.41) | HSD11B1TSHRPTGS1PTGS2ALDH1A1 | |
| SCHEMBL9910775 | 0.71 | HSD11B1 (0.47) | HSD11B1TSHRPTGS1PTGS2ALDH1A1 | |
| SCHEMBL15875128 | 0.69 | KDM4E (0.49) | HSD11B1TSHRPTGS1PTGS2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590944-A1 | 1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | Actelion Pharmaceuticals Ltd. (CH) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004722-A1 | 1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2012-01-12 | — | — | WO | disclosed |