Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL531 | 0.97 | LOXL2 (0.58) | LOXL2CYP2A6GSK3BMAOBCYP19A1 | |
| SCHEMBL5486578 | 0.95 | LOXL2 (0.56) | LOXL2CYP2A6GSK3BMAOBCYP19A1 | |
| SCHEMBL1078454 | 0.91 | LOXL2 (0.52) | LOXL2CYP2A6GSK3BMAOBCYP19A1 | |
| SCHEMBL10929655 | 0.85 | LOXL2 (0.47) | LOXL2CYP2A6GSK3BMAOBCYP19A1 | |
| SCHEMBL3264554 | 0.85 | PARP15 (0.49) | LOXL2CYP2A6GSK3BMAOBCYP19A1 | |
| SCHEMBL450762 | 0.85 | KIF11 (0.47) | LOXL2CYP2A6GSK3BMAOBCYP19A1 | |
| SCHEMBL10929666 | 0.85 | LOXL2 (0.47) | LOXL2CYP2A6GSK3BMAOBCYP19A1 | |
| SCHEMBL507651 | 0.82 | GSK3B (0.59) | LOXL2CYP2A6GSK3BALDH1A1CA2 | |
| SCHEMBL10925694 | 0.82 | MAOB (0.68) | MAOBCYP19A1MAOA | |
| SCHEMBL9432333 | 0.80 | MAOB (0.46) | LOXL2CYP2A6GSK3BMAOBCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010186-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |