Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 1/20 | 0.63 |
| ▸ | P2RX1 | P51575 | 8/20 | 0.57 |
| ▸ | JUN | P05412 | 3/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.56 |
| ▸ | RELA | Q04206 | 3/20 | 0.56 |
| ▸ | P2RX4 | Q99571 | 4/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.50 |
| ▸ | TMPRSS4 | Q9NRS4 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | CHUK | O15111 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MYLK | Q15746 | 1/20 | 0.50 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3227232 | 0.88 | MAPT (0.63) | CXCR2P2RX1P2RX4P2RX7TMPRSS4 | |
| SCHEMBL3218512 | 0.88 | CXCR2 (0.72) | CXCR2HDAC3HDAC8HDAC6MAPT | |
| SCHEMBL3218645 | 0.81 | CXCR2 (0.62) | CXCR2TMPRSS4MEN1KDRKMT2A | |
| SCHEMBL11799771 | 0.80 | P2RX1 (0.71) | P2RX1JUNNFKB1NFKB2RELA | |
| SCHEMBL3218503 | 0.80 | CXCR2 (0.64) | CXCR2TMPRSS4MEN1KDRKMT2A | |
| SCHEMBL3223167 | 0.79 | CXCR2 (0.63) | CXCR2MEN1KMT2A | |
| SCHEMBL3228209 | 0.77 | CXCR2 (1.00) | CXCR2MEN1KMT2A | |
| SCHEMBL3217766 | 0.77 | CXCR2 (0.73) | CXCR2MEN1KMT2AHDAC8HDAC6 | |
| SCHEMBL3227245 | 0.77 | CXCR2 (0.78) | CXCR2MEN1KMT2AMAPT | |
| SCHEMBL3227775 | 0.77 | CXCR2 (0.72) | CXCR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100063105-A1 | PHARMACEUTICAL USES AND SYNTHESIS OF NICOTINANILIDE-N-OXIDES | UCB SA (GB) | 2010-03-11 | — | — | US | disclosed |
| US-7141590-B2 | Pharmaceutical uses and synthesis of nicotinanilide-N-oxides | UCB SA (GB) | 2006-11-28 | — | — | US | disclosed |
| US-20050026965-A1 | Pharmaceutical uses and synthesis of nicotinanilide-N-oxides | DARWIN DISCOVERY LIMITED (GB) | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063105-A1 | PHARMACEUTICAL USES AND SYNTHESIS OF NICOTINANILIDE-N-OXIDES | NNT, NAPRT, NNMT | CXCR2 1447/4885P2RX1 180/4885JUN 3993/4885 |
| US-20050026965-A1 | Pharmaceutical uses and synthesis of nicotinanilide-N-oxides | NNT, NAPRT, NNMT | CXCR2 1447/4885P2RX1 180/4885JUN 3993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.