Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2540218 | 0.93 | USP2 (0.41) | USP2LMNATSHRSMN1; SMN2SLC27A1 | |
| SCHEMBL2547142 | 0.93 | USP2 (0.42) | USP2LMNATSHRSMN1; SMN2CLK1 | |
| SCHEMBL2540214 | 0.91 | USP2 (0.40) | USP2LMNATSHRSMN1; SMN2SLC27A1 | |
| SCHEMBL2543731 | 0.90 | USP2 (0.39) | USP2LMNATSHRSMN1; SMN2SLC27A1 | |
| SCHEMBL2541916 | 0.90 | USP2 (0.39) | USP2LMNATSHRSMN1; SMN2SLC27A1 | |
| SCHEMBL2539010 | 0.90 | CLK1 (0.47) | USP2LMNATSHRSMN1; SMN2SLC27A1 | |
| SCHEMBL2538982 | 0.90 | USP2 (0.40) | USP2LMNATSHRSMN1; SMN2SLC27A1 | |
| SCHEMBL2546149 | 0.90 | LMNA (0.39) | USP2LMNATSHRSMN1; SMN2SLC27A1 | |
| SCHEMBL2543264 | 0.90 | USP2 (0.40) | USP2LMNATSHRSMN1; SMN2SLC27A1 | |
| SCHEMBL2547871 | 0.89 | ALDH1A1 (0.44) | USP2LMNATSHRSMN1; SMN2SLC27A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010007318-A2 | NOVEL IMIDAZO[1,2-A]PYRIMIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF, USE THEREOF AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS MET INHIBITORS | SANOFI-AVENTIS (FR) | 2010-01-21 | — | — | WO | disclosed |