Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 10/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 4/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.31 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6578876 | 0.82 | POLB (0.46) | ESR2CYP2C9CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL22929 | 0.82 | — | — | |
| SCHEMBL1443559 | 0.79 | ESR2 (0.39) | ESR2POLBESR1 | |
| SCHEMBL3226714 | 0.79 | ESR2 (0.37) | ESR2CYP2C9APPCYP3A4CYP2D6 | |
| SCHEMBL3233086 | 0.78 | ESR2 (0.41) | ESR2POLBESR1SLC18A3 | |
| SCHEMBL3234140 | 0.76 | ESR2 (0.38) | ESR2CYP2C9ESR1 | |
| SCHEMBL1089522 | 0.76 | ESR2 (0.59) | ESR2CYP2C9CYP3A4POLBESR1 | |
| SCHEMBL25039518 | 0.75 | ESR2 (0.48) | ESR2CYP2C9APPCYP3A4CYP2D6 | |
| SCHEMBL3148250 | 0.75 | ESR2 (0.75) | ESR2CYP2C9CYP3A4CYP2D6ESR1 | |
| SCHEMBL16152681 | 0.75 | ESR2 (0.48) | ESR2CYP2C9APPCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010019828-A1 | GLUCAGON RECEPTOR ANTAGONISTS | METABASIS THERAPEUTICS, INC. (US) | 2010-02-18 | — | — | WO | claimed |
| WO-2010019828-A1 | GLUCAGON RECEPTOR ANTAGONISTS | METABASIS THERAPEUTICS, INC. (US) | 2010-02-18 | — | — | WO | disclosed |