Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.61 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.61 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.61 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.61 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.61 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.61 |
| ▸ | CDK4 | P11802 | 2/20 | 0.60 |
| ▸ | CCND1 | P24385 | 2/20 | 0.60 |
| ▸ | GABRP | O00591 | 3/20 | 0.59 |
| ▸ | GABRD | O14764 | 3/20 | 0.59 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.59 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.59 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.59 |
| ▸ | GABRE | P78334 | 3/20 | 0.59 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.59 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.59 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.59 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31485483 | 0.88 | GABRA1 (0.54) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL29388457 | 0.84 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL3228276 | 0.84 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL27074281 | 0.84 | ACHE (0.59) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Iodide SCHEMBL9958847 | 0.83 | GABRA1 (0.57) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8120408 | 0.75 | CDK4 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL29848541 | 0.75 | CDK4 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1198673 | 0.75 | GABRA1 (0.53) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Carbazole SCHEMBL18684843 | 0.75 | CHUK (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| Norharmane SCHEMBL9486853 | 0.75 | CHUK (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015588-A1 | BENZYL-SUBSTITUTED TETRACYCLIC HETEROCYCLIC COMPOUNDS | NYCOMED GMBH (DE) | 2010-02-11 | — | — | WO | disclosed |