Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 6/20 | 0.64 |
| ▸ | RARG | P13631 | 6/20 | 0.64 |
| ▸ | RARA | P10276 | 5/20 | 0.64 |
| ▸ | RXRA | P19793 | 18/20 | 0.56 |
| ▸ | RXRB | P28702 | 9/20 | 0.56 |
| ▸ | RXRG | P48443 | 9/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3234003 | 1.00 | RARB (0.64) | RARBRARGRARARXRARXRB | |
| SCHEMBL7931985 | 0.79 | RARB (0.62) | RARBRARGRARARXRARXRB | |
| SCHEMBL10841477 | 0.78 | RARB (1.00) | RARBRARGRARARXRARXRB | |
| SCHEMBL156460 | 0.78 | RARB (1.00) | RARBRARGRARARXRARXRB | |
| Hydrochloric Acid SCHEMBL4432609 | 0.77 | RARB (0.97) | RARBRARGRARARXRARXRB | |
| SCHEMBL727923 | 0.74 | RARB (0.70) | RARBRARGRARARXRARXRB | |
| SCHEMBL7023945 | 0.73 | RARB (0.55) | RARBRARGRARARXRARXRB | |
| SCHEMBL30054740 | 0.73 | RXRA (1.00) | RARBRARGRARARXRARXRB | |
| SCHEMBL726140 | 0.73 | RXRA (1.00) | RARBRARGRARARXRARXRB | |
| SCHEMBL9319026 | 0.72 | RXRA (0.77) | RARBRARGRARARXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130157260-A1 | IDENTIFICATION OF COMPOUNDS THAT REGULATE APOPTOSIS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2013-06-20 | — | — | US | disclosed |
| US-8273705-B2 | Conversion of apoptotic proteins | THE BURNHAM INSTITUTE (US) | 2012-09-25 | — | — | US | disclosed |
| US-20100292145-A1 | METHODS OF REGULATING APOPTOSIS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2010-11-18 | — | — | US | disclosed |
| US-7745574-B2 | Compounds that regulate apoptosis | THE BURNHAM INSTITUTE (US) | 2010-06-29 | — | — | US | disclosed |
| WO-2008154207-A9 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-04-22 | — | — | WO | disclosed |
| US-20090215984-A1 | CONVERSION OF APOPTOTIC PROTEINS | THE BURNHAM INSTITUTE (US) | 2009-08-27 | — | — | US | disclosed |
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-05-07 | — | — | US | disclosed |
| US-7491700-B2 | Conversion of apoptotic proteins | THE BURNHAM INSTITUTE (US) | 2009-02-17 | — | — | US | disclosed |
| WO-2008154207-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2008-12-18 | — | — | WO | disclosed |
| US-20070117753-A1 | CONVERSION OF APOPTOTIC PROTEINS | THE BURNHAM INSTITUTE (US) | 2007-05-24 | — | — | US | disclosed |
| US-20070054863-A1 | Compounds that regulate apoptosis | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2007-03-08 | — | — | US | disclosed |
| US-7176277-B2 | Conversion of apoptotic proteins | THE BURNHAM INSTITUTE (US) | 2007-02-13 | — | — | US | disclosed |
| WO-2006124537-A1 | COMPOUNDS THAT REGULATE APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2006-11-23 | — | — | WO | disclosed |
| US-20060193864-A1 | Conversion of apoptotic proteins | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2006-08-31 | — | — | US | disclosed |
| US-6994979-B2 | Conversion of apoptotic proteins | THE BURNHAM INSTITUTE (US) | 2006-02-07 | — | — | US | disclosed |
| US-20040220097-A1 | Conversion of apoptotic proteins | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-11-04 | — | — | US | disclosed |
| WO-2004052920-A9 | CONVERSION OF APOPTOTIC PROTEINS | BURNHAM INST (US) | 2004-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | BCL2, BAX, BAD | RARB 1796/4885RARG 2219/4885RARA 2968/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.