Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.59 |
| ▸ | PARP1 | P09874 | 3/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.51 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2441761 | 0.86 | ABCG2 (0.50) | KIF11PARP1ABCG2PBRM1LMNA | |
| SCHEMBL2444761 | 0.85 | PBRM1 (0.68) | ABCG2PBRM1KMT2AALDH1A1MEN1 | |
| SCHEMBL14376207 | 0.82 | KIF11 (0.86) | KIF11PARP1ABCG2RAB9AKMT2A | |
| SCHEMBL30571577 | 0.82 | KIF11 (0.86) | KIF11PARP1ABCG2RAB9AKMT2A | |
| SCHEMBL3230702 | 0.79 | PBRM1 (0.71) | PARP1DYRK1AABCG2PBRM1CSNK2A1 | |
| SCHEMBL2442637 | 0.79 | PBRM1 (0.49) | ABCG2PBRM1ALDH1A1LMNADHFR | |
| SCHEMBL2445608 | 0.76 | PIM1 (0.53) | DYRK1AABCG2PBRM1KMT2AALDH1A1 | |
| SCHEMBL4725998 | 0.75 | KIF11 (0.84) | KIF11PARP1DYRK1ARAB9AKMT2A | |
| SCHEMBL29708168 | 0.75 | KIF11 (0.84) | KIF11PARP1DYRK1ARAB9AKMT2A | |
| SCHEMBL9485757 | 0.75 | MPL (0.61) | KIF11PBRM1KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458392-B9 | ACRIDONES AS INHIBITORS OF IMPDH ENZYME | BRISTOL MYERS SQUIBB CO (US) | 2010-07-28 | — | — | EP | claimed |
| EP-1458392-B1 | ACRIDONES AS INHIBITORS OF IMPDH ENZYME | BRISTOL MYERS SQUIBB CO (US) | 2009-09-02 | — | — | EP | claimed |
| EP-1458392-B9 | ACRIDONES AS INHIBITORS OF IMPDH ENZYME | BRISTOL MYERS SQUIBB CO (US) | 2010-07-28 | — | — | EP | disclosed |
| EP-1458392-B1 | ACRIDONES AS INHIBITORS OF IMPDH ENZYME | BRISTOL MYERS SQUIBB CO (US) | 2009-09-02 | — | — | EP | disclosed |