Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.71 |
| ▸ | PARP1 | P09874 | 3/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 5/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 2/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MPL | P40238 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10857797 | 0.84 | PBRM1 (0.69) | PBRM1PARP1ABCG2KDM4EGFER | |
| SCHEMBL10863663 | 0.84 | PBRM1 (0.69) | PBRM1ABCG2KDM4EGFERMAPT | |
| SCHEMBL11068316 | 0.84 | PARP1 (0.54) | PBRM1PARP1IMPDH2DYRK1ATTR | |
| SCHEMBL8143454 | 0.84 | PBRM1 (0.69) | PBRM1DYRK1AABCG2KDM4E | |
| SCHEMBL7565777 | 0.84 | PBRM1 (0.69) | PBRM1PARP1ABCG2KDM4EGFER | |
| SCHEMBL2444365 | 0.84 | PBRM1 (0.69) | PBRM1PARP1DYRK1AABCG2KDM4E | |
| SCHEMBL4943278 | 0.83 | PBRM1 (1.00) | PBRM1PARP1DYRK1AABCG2KDM4E | |
| SCHEMBL29801740 | 0.83 | PBRM1 (1.00) | PBRM1PARP1DYRK1AABCG2KDM4E | |
| SCHEMBL3234597 | 0.80 | PARP1 (0.67) | PBRM1PARP1IMPDH2TTRKDM4E | |
| SCHEMBL3234002 | 0.79 | KIF11 (0.59) | PBRM1PARP1IMPDH2DYRK1AABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458392-B9 | ACRIDONES AS INHIBITORS OF IMPDH ENZYME | BRISTOL MYERS SQUIBB CO (US) | 2010-07-28 | — | — | EP | claimed |
| EP-1458392-B1 | ACRIDONES AS INHIBITORS OF IMPDH ENZYME | BRISTOL MYERS SQUIBB CO (US) | 2009-09-02 | — | — | EP | claimed |