Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3234280 | 0.90 | CHRM1 (0.49) | CHRM1KDM4EALDH1A1SMN1; SMN2FABP4 | |
| SCHEMBL3234399 | 0.89 | CHRM1 (0.63) | CHRM1MAPTTP53 | |
| SCHEMBL3234297 | 0.88 | CHRM1 (0.48) | CHRM1KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3236698 | 0.88 | CHRM1 (0.54) | CHRM1SMN1; SMN2 | |
| SCHEMBL2489039 | 0.87 | CHRM1 (0.74) | CHRM1MAPTTP53 | |
| SCHEMBL3234252 | 0.87 | CHRM1 (0.44) | CHRM1MAPTTP53P2RX7 | |
| SCHEMBL3234599 | 0.86 | CHRM1 (0.44) | CHRM1ALDH1A1POLBMAPTP2RX7 | |
| SCHEMBL3236068 | 0.86 | CHRM1 (0.51) | CHRM1MAPTP2RX7 | |
| SCHEMBL3234234 | 0.86 | CHRM1 (0.76) | CHRM1KDM4EALDH1A1SMN1; SMN2FABP4 | |
| SCHEMBL3232234 | 0.85 | CHRM1 (0.56) | CHRM1ALDH1A1SMN1; SMN2POLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |