Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.48 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3235201 | 0.84 | CHRM1 (0.65) | CHRM1RORCAKR1B1MEN1CYP1A2 | |
| SCHEMBL3242044 | 0.82 | CHRM1 (0.49) | CHRM1 | |
| SCHEMBL3230362 | 0.81 | AKR1B1 (0.43) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL2487495 | 0.81 | CHRM1 (0.55) | CHRM1 | |
| SCHEMBL3237170 | 0.81 | CHRM1 (0.46) | CHRM1MAPTTP53 | |
| SCHEMBL2490480 | 0.80 | CHRM1 (0.76) | CHRM1CHRM5 | |
| SCHEMBL3233866 | 0.80 | AKR1B1 (0.53) | AKR1B1MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL3239675 | 0.79 | CHRM1 (0.57) | CHRM1CYP1A2CYP2C9MAPTTP53 | |
| SCHEMBL2490472 | 0.79 | CHRM1 (0.52) | CHRM1RORCMEN1KMT2AMAPT | |
| SCHEMBL3242291 | 0.78 | CHRM1 (0.46) | CHRM1MEN1KMT2ATP53RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |