Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13457185 | 0.77 | ROCK2 (0.77) | ROCK2ROCK1MAPK10 | |
| SCHEMBL3262426 | 0.77 | ROCK2 (0.71) | ROCK2ROCK1 | |
| SCHEMBL1519127 | 0.77 | ROCK2 (0.62) | ROCK2ROCK1AKT1MAPK8MAPK10 | |
| SCHEMBL3359796 | 0.76 | ROCK2 (0.51) | ROCK2ROCK1ALOX15ALOX12MTNR1A | |
| SCHEMBL3356239 | 0.75 | ROCK2 (0.56) | ROCK2ROCK1ALOX15ALOX12MTNR1A | |
| SCHEMBL1519296 | 0.75 | ROCK2 (0.56) | ROCK2ROCK1BRAFAKT1MAPK8 | |
| SCHEMBL21594807 | 0.74 | CYP19A1 (0.54) | ALOX15ALOX12LMNAALOX15BCYP19A1 | |
| SCHEMBL3239971 | 0.74 | ROCK2 (0.56) | ROCK2ROCK1AKT1MAPK8MAPK10 | |
| SCHEMBL1648128 | 0.72 | ROCK2 (0.46) | ROCK2ROCK1MTNR1AAKT1MAPK8 | |
| SCHEMBL1519397 | 0.72 | ROCK2 (0.55) | ROCK2ROCK1BRAFAKT1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010024903-A1 | BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-03-04 | — | — | WO | disclosed |