Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.54 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.53 |
| ▸ | ATR | Q13535 | 2/20 | 0.52 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.48 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.48 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.48 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.48 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3121347 | 1.00 | MET (0.54) | METMAP4K3ATRMAP4K2MAP3K1 | |
| SCHEMBL3109427 | 0.91 | MET (0.52) | METMAP4K3ATRMAP4K2MAP3K1 | |
| SCHEMBL30454392 | 0.90 | MET (0.64) | METMAP4K3ATRMAP4K2MAP3K1 | |
| SCHEMBL489251 | 0.90 | MET (0.64) | METMAP4K3ATRMAP4K2MAP3K1 | |
| SCHEMBL13276216 | 0.88 | MET (0.56) | METMAP4K3MAP4K2MAP3K1AAK1 | |
| SCHEMBL1900138 | 0.88 | MAP4K3 (0.62) | METMAP4K3ATRMAP4K2MAP3K1 | |
| SCHEMBL3243135 | 0.88 | MAP4K3 (0.62) | METMAP4K3ATRMAP4K2MAP3K1 | |
| SCHEMBL3117593 | 0.85 | MET (0.72) | METMAP4K2MAP3K1AAK1Q6ZSR9 | |
| SCHEMBL1905237 | 0.85 | MET (0.72) | METMAP4K2MAP3K1AAK1Q6ZSR9 | |
| SCHEMBL488689 | 0.85 | MET (0.57) | METMAP4K3ATRMAP4K2MAP3K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786785-B9 | ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | PFIZER (US) | 2013-05-22 | — | — | EP | disclosed |
| EP-1786785-B1 | ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | PFIZER (US) | 2010-04-07 | — | — | EP | disclosed |