Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.62 |
| ▸ | MET | P08581 | 11/20 | 0.59 |
| ▸ | JAK2 | O60674 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.49 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.49 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.49 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1900138 | 1.00 | MAP4K3 (0.62) | MAP4K3METJAK2KCNH2ALK | |
| SCHEMBL489251 | 0.91 | MET (0.64) | MAP4K3METKCNH2ALKATR | |
| SCHEMBL30454392 | 0.91 | MET (0.64) | MAP4K3METKCNH2ALKATR | |
| SCHEMBL13276216 | 0.90 | MET (0.56) | MAP4K3METJAK2CHEK2MAP4K2 | |
| SCHEMBL488862 | 0.89 | MET (0.74) | MAP4K3METJAK2ALKCHEK2 | |
| SCHEMBL30454746 | 0.89 | MET (0.74) | MAP4K3METJAK2ALKCHEK2 | |
| SCHEMBL3235697 | 0.88 | MET (0.54) | MAP4K3METKCNH2CHEK2ATR | |
| SCHEMBL488829 | 0.88 | MET (0.61) | MAP4K3METCHEK2MAP4K2MAP3K1 | |
| SCHEMBL30454879 | 0.88 | MET (0.61) | MAP4K3METCHEK2MAP4K2MAP3K1 | |
| SCHEMBL3121347 | 0.88 | MET (0.54) | MAP4K3METKCNH2CHEK2ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786785-B9 | ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | PFIZER (US) | 2013-05-22 | — | — | EP | disclosed |
| EP-1786785-B1 | ENANTIOMERICALLY PURE AMINOHETEROARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | PFIZER (US) | 2010-04-07 | — | — | EP | disclosed |
| EP-2143441-A1 | Combination of a c-Met antagonist and an aminoheteroaryl compound for the treatment of cancer | Pierre Fabre Medicament (FR) | 2010-01-13 | — | — | EP | disclosed |