Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | OGA | O60502 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9766077 | 0.85 | SIGMAR1 (0.54) | SIGMAR1KDM4ECYP1A2GAACYP2C9 | |
| Hydrochloric Acid SCHEMBL10844029 | 0.82 | SIGMAR1 (0.41) | SIGMAR1KDM4ECYP1A2GAACYP2C9 | |
| Bmy-14802 SCHEMBL8457738 | 0.73 | SIGMAR1 (1.00) | SIGMAR1KDM4ECYP1A2GAACYP2C9 | |
| Bmy-14802 SCHEMBL467229 | 0.73 | SIGMAR1 (1.00) | SIGMAR1KDM4ECYP1A2GAACYP2C9 | |
| Bmy-14802 SCHEMBL10843594 | 0.72 | SIGMAR1 (0.97) | SIGMAR1KDM4ECYP1A2GAACYP2C9 | |
| Bmy-14802 SCHEMBL466842 | 0.72 | SIGMAR1 (0.97) | SIGMAR1KDM4ECYP1A2GAACYP2C9 | |
| SCHEMBL9602967 | 0.72 | SIGMAR1 (0.79) | SIGMAR1KDM4ECYP1A2GAACYP2C9 | |
| SCHEMBL30350966 | 0.70 | SIGMAR1 (0.66) | SIGMAR1KDM4ECYP1A2GAACYP2C9 | |
| SCHEMBL9766050 | 0.68 | SIGMAR1 (0.71) | SIGMAR1KDM4ECYP1A2GAACYP2C9 | |
| SCHEMBL9765987 | 0.68 | SIGMAR1 (0.75) | SIGMAR1KDM4ECYP1A2GAACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015040-A1 | THERAPY AND PREVENTION OF TDP-43 PROTEINOPATHY | POWMRI LTD (AU) | 2010-02-11 | — | — | WO | claimed |
| WO-2010015040-A1 | THERAPY AND PREVENTION OF TDP-43 PROTEINOPATHY | POWMRI LTD (AU) | 2010-02-11 | — | — | WO | disclosed |
| WO-1994016685-A1 | OPHTHALMIC USES OF SIGNA AGONISTS | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 1994-08-04 | — | — | WO | disclosed |