Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 5/20 | 0.37 |
| ▸ | PDE4A | P27815 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3242044 | 0.93 | CHRM1 (0.49) | CHRM1PDE7APDE4APTGDR2 | |
| SCHEMBL3242291 | 0.86 | CHRM1 (0.46) | CHRM1PDE7APDE4ATP53PTGDR2 | |
| SCHEMBL3239675 | 0.85 | CHRM1 (0.57) | CHRM1TP53MAPTGAA | |
| SCHEMBL3237168 | 0.82 | CHRM1 (0.66) | CHRM1PDE7APDE4A | |
| SCHEMBL3230518 | 0.82 | CHRM1 (0.48) | CHRM1KCNH2PDE7APDE4ATP53 | |
| SCHEMBL2490524 | 0.81 | CHRM1 (0.71) | CHRM1TP53 | |
| SCHEMBL3238778 | 0.81 | CHRM1 (0.48) | CHRM1TP53MAPT | |
| SCHEMBL3238090 | 0.80 | CHRM1 (0.46) | CHRM1PDE7APDE4APTGDR2 | |
| SCHEMBL3242119 | 0.80 | PTGDR2 (0.48) | KCNH2PDE7APDE4ATP53PTGDR2 | |
| SCHEMBL3237319 | 0.79 | CHRM1 (0.53) | CHRM1PDE7ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |