Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.64 |
| ▸ | MAOA | P21397 | 3/20 | 0.64 |
| ▸ | MMP2 | P08253 | 1/20 | 0.55 |
| ▸ | MMP9 | P14780 | 1/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TYR | P14679 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29941904 | 0.83 | MAOB (0.68) | MAOBMAOAMMP2MMP9ADAM17 | |
| SCHEMBL29234432 | 0.83 | MAOB (0.64) | MAOBMAOAMMP2MMP9ADAM17 | |
| SCHEMBL27625488 | 0.80 | MMP2 (0.67) | MAOBMAOAMMP2MMP9ADAM17 | |
| SCHEMBL13612673 | 0.80 | MAOA (0.61) | MAOBMAOAMMP2MMP9ADAM17 | |
| SCHEMBL1619109 | 0.79 | MAOB (0.67) | MAOBMAOAMMP2MMP9ADAM17 | |
| SCHEMBL30594160 | 0.79 | MAOB (0.67) | MAOBMAOAMMP2MMP9ADAM17 | |
| SCHEMBL293739 | 0.78 | MMP2 (0.60) | MAOBMAOAMMP2MMP9ADAM17 | |
| SCHEMBL25306495 | 0.77 | MAOA (0.58) | MAOBMAOAMMP2MMP9ADAM17 | |
| SCHEMBL294595 | 0.77 | MAOA (0.58) | MAOBMAOAMMP2MMP9ADAM17 | |
| SCHEMBL765821 | 0.77 | MAOA (0.58) | MAOBMAOAMMP2MMP9ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2236619-A2 | BCL2L12 polypeptide activators and inhibitors | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2010-10-06 | — | — | EP | disclosed |
| US-7595158-B2 | Bcl2L12 polypeptide activators and inhibitors | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2009-09-29 | — | — | US | disclosed |
| EP-1618217-A4 | BCL2L12 POLYPEPTIDE ACTIVATORS AND INHIBITORS | DANA FARBER CANCER INST INC (US) | 2008-11-26 | — | — | EP | disclosed |
| US-20060252053-A1 | Bcl2L12 polypeptide activators and inhibitors | DANA-FARBER CANCER INSTITUTE, INC. | 2006-11-09 | — | — | US | disclosed |
| EP-1618217-A2 | BCL2L12 POLYPEPTIDE ACTIVATORS AND INHIBITORS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004096991-A2 | BCL2L12 POLYPEPTIDE ACTIVATORS AND INHIBITORS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2004-11-11 | — | — | WO | disclosed |