Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.34 |
| ▸ | YTHDF2 | Q9Y5A9 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24121974 | 0.81 | PDPK1 (0.46) | PDPK1DYRK1AYTHDC1YTHDF2ADORA2A | |
| SCHEMBL10120030 | 0.78 | PI4KA (0.44) | KDM4EPDPK1ALDH1A1MAPTDYRK1A | |
| SCHEMBL11330441 | 0.76 | PDPK1 (0.42) | PDPK1YTHDC1YTHDF2ADORA2AADORA2B | |
| SCHEMBL3231071 | 0.76 | KDM4E (0.36) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3241299 | 0.76 | KDM4E (0.36) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL21347895 | 0.73 | PDPK1 (0.43) | PDPK1YTHDC1YTHDF2ADORA2AADORA2B | |
| SCHEMBL24908744 | 0.73 | PDPK1 (0.40) | PDPK1YTHDC1YTHDF2ADORA2AADORA2B | |
| SCHEMBL11337092 | 0.73 | TP53 (0.49) | PDPK1ALDH1A1LMNAYTHDC1YTHDF2 | |
| SCHEMBL4574090 | 0.71 | HCAR2 (0.41) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL31194340 | 0.69 | YTHDC1 (0.38) | PDPK1DYRK1AYTHDC1ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4282361-A | Synthesis for 7-alkylamino-3-methylpyrazolo [4,3-d]pyrimidines | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1981-08-04 | — | — | US | claimed |
| CN-113039182-B | Inhibitors of YAP/TAZ-TEAD interactions and their use in cancer treatment | 伊文蒂瓦公司 | 2024-02-20 | — | — | CN | disclosed |
| CN-113039182-A | Inhibitors of YAP/TAZ-TEAD interaction and their use in cancer treatment | 伊文蒂瓦公司 | 2021-06-25 | — | — | CN | disclosed |
| EP-1475094-B1 | Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use | USTAV EX BOTAN AKADEMIE VED CE (CZ) | 2010-07-28 | — | — | EP | disclosed |
| US-20070167466-A1 | \"Pyrazolo [4,3-d]pyrimidines, processes for their preparation and methods of use\ | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2007-07-19 | — | — | US | disclosed |
| WO-2004098608-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES, PROCESSES FOR THEIR PREPARATION AND METHODS OF USE | ÚSTAV EXPERIMENTALNI BOTANIKY AKADEMIE VED CESKE REPUBLIKY (CZ) | 2004-11-18 | — | — | WO | disclosed |
| EP-1475094-A1 | Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use | Ustav Experimentalni Botaniky Akademie ved Ceské Republiky (CZ) | 2004-11-10 | — | — | EP | disclosed |
| US-4282361-A | Synthesis for 7-alkylamino-3-methylpyrazolo [4,3-d]pyrimidines | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 1981-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167466-A1 | \"Pyrazolo [4,3-d]pyrimidines, processes for their preparation and methods of use\ | CBR3, PYM1, PNPO | KDM4E 2102/4885PDPK1 3929/4885ALDH1A1 1636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.