Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.41 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.41 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.41 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | NEK2 | P51955 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3230163 | 0.92 | GUCY1B2 (0.44) | SMN1; SMN2RAB9AGUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3235879 | 0.91 | SMN1; SMN2 (0.52) | SMN1; SMN2RAB9AGUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3238569 | 0.88 | L3MBTL1 (0.46) | SMN1; SMN2RAB9AGUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3238419 | 0.88 | SMN1; SMN2 (0.46) | SMN1; SMN2RAB9AKMT2AGUCY1B2GUCY1A2 | |
| SCHEMBL3230950 | 0.85 | RAB9A (0.47) | SMN1; SMN2RAB9AGUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3236498 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9AGUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3231021 | 0.84 | SMN1; SMN2 (0.44) | SMN1; SMN2RAB9AGUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3239261 | 0.84 | GUCY1B2 (0.47) | SMN1; SMN2RAB9AGUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3224931 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9AGUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3237560 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2RAB9ANPC1NEK2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | claimed |
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | claimed |
| EP-2594270-A2 | The use of sGC stimulators, sGC activators, alone and combinations with PDE5 inhibitors for the treatment of systemic sclerosis (SSc) | BIP Patents (DE) | 2013-05-22 | — | — | EP | disclosed |
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |