Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL7464181 | 0.98 | TRPA1 (0.38) | TRPA1 | |
| SCHEMBL27596728 | 0.98 | TRPA1 (0.38) | TRPA1 | |
| Hydrochloric Acid SCHEMBL10932771 | 0.98 | TRPA1 (0.38) | TRPA1 | |
| SCHEMBL214255 | 0.77 | TRPA1 (0.42) | TRPA1 | |
| SCHEMBL8822807 | 0.72 | RPS6KA3 (0.34) | — | |
| SCHEMBL30218263 | 0.70 | TRPA1 (0.32) | TRPA1 | |
| SCHEMBL29394860 | 0.70 | TRPA1 (0.32) | TRPA1 | |
| SCHEMBL9850771 | 0.69 | — | — | |
| SCHEMBL8106506 | 0.68 | TRPA1 (0.33) | TRPA1 | |
| SCHEMBL620184 | 0.67 | TRPA1 (0.41) | TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1096 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106543102-A | 1,5 benzothiazepines analog derivatives and its application | 石家庄学院 | 2017-03-29 | — | — | CN | claimed |
| CN-101020706-B | Helicid medicine containing 1,5-benzothioazatro cycle with tranquilizing activity and its prepn process | UNIV SICHUAN | 2013-03-06 | — | — | CN | claimed |
| EP-1173205-B1 | AN ORAL FORMULATION FOR ILEUM ADMINISTERING COMPRISING AN INHIBITOR COMPOUND OF THE ILEAL BILE ACID TRANSPORT | ASTRAZENECA AB (SE) | 2005-06-01 | — | — | EP | claimed |
| WO-2003031376-A1 | SOLID PHASE SYNTHESIS OF SUBSTITUTED 1,5-BENZODIAZEPINE-2-ONE AND 1,5-BENZOTHIAZEPINE-2-ONE | AVENTIS PHARMACEUTICALS INC. (US) | 2003-04-17 | — | — | WO | claimed |
| US-6197953-B1 | ESTER INTERCHANGE, CRYSTALLIZATION, ISOMERIZATION; PREPARING 1,5-BENZOTHIAZEPINE DERIVATIVES | TANABE SEIYAKU CO., LTD. (JP) | 2001-03-06 | — | — | US | claimed |
| EP-0988297-A2 | PROCESS FOR PREPARING OPTICALLY ACTIVE PHENYLOXIRANE COMPOUNDS | Tanabe Seiyaku Co., Ltd. (JP) | 2000-03-29 | — | — | EP | claimed |
| EP-0796853-B1 | Process for the preparation of a benzothiazepine | DSM NV (NL) | 2000-01-19 | — | — | EP | claimed |
| US-5929068-A | INTERMEDIATES FOR PREPARING DILTIAZEM CAN BE READILY OBTAINED WITHOUT USING AN EXPENSIVE OPTICALLY ACTIVE RESOLVING AGENT | TANABE SEIYAKU CO., LTD. (JP) | 1999-07-27 | — | — | US | claimed |
| EP-0778273-B1 | Process for preparing optically active 3-hydroxy-1,5-benzothiazepine derivative and intermediate therefor | TANABE SEIYAKU CO (JP) | 1999-01-27 | — | — | EP | claimed |
| US-5859241-A | Process for the preparation of a benzothiazepine | DSM N.V. (NL) | 1999-01-12 | — | — | US | claimed |
| EP-0182273-A1 | 1,5-Benzothiazepine derivatives, a process for preparing the same, pharmaceutical compositions as well as the use thereof | Tanabe Seiyaku Co., Ltd. (JP) | 1986-05-28 | — | — | EP | claimed |
| US-4590188-A | HYPOTENSIVES, VASODILATORS | TANABE SEIYAKU CO., LTD. (JP) | 1986-05-20 | — | — | US | claimed |
| US-4585768-A | ANTICOAGULANTS | TANABE SEIYAKU CO., LTD. (JP) | 1986-04-29 | — | — | US | claimed |
| EP-0158340-A2 | Novel 1,5-benzothiazepine derivative, processes for preparing the same and pharmaceutical compositions | Tanabe Seiyaku Co., Ltd. (JP) | 1985-10-16 | — | — | EP | claimed |
| EP-0158339-A2 | 1,5-Benzothiazephine derivatives, processes for preparing the same and pharmaceutical compositions | Tanabe Seiyaku Co., Ltd. (JP) | 1985-10-16 | — | — | EP | claimed |
| US-4547495-A | 1,5-Benzothiazepines with cardiovascular utility, and pharmaceutical compositions containing them | SCHIAPPARELLI FARMACEUTICI S.P.A. (IT) | 1985-10-15 | — | — | US | claimed |
| EP-0154838-A1 | Novel 1,5-benzothiazepine derivatives, processes for preparing the same and pharmaceutical compositions | Tanabe Seiyaku Co., Ltd. (JP) | 1985-09-18 | — | — | EP | claimed |
| EP-0098892-A1 | Process for preparing 1,5-benzothiazepine derivatives | Tanabe Seiyaku Co., Ltd. (JP) | 1984-01-25 | — | — | EP | claimed |
| US-4416819-A | Process for preparing 1,5-benzothiazephine derivatives | TANABE SEIYAKU CO., LTD. (JP) | 1983-11-22 | — | — | US | claimed |
| US-4264497-A | ANTICHOLINERGIC, ANTISPASMODIC, ANTIULCER AND ANTISECRETORY AGENTS | MARUKO SEIYAKU CO., LTD. (JP) | 1981-04-28 | — | — | US | claimed |