Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 5/20 | 0.49 |
| ▸ | HTR2A | P28223 | 3/20 | 0.49 |
| ▸ | HTR2B | P41595 | 3/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18324783 | 0.81 | KDM4E (0.47) | KDM4EATMBRD4ALDH1A1POLB | |
| SCHEMBL6529902 | 0.80 | KDM4E (1.00) | KDM4EATMBRD4ALDH1A1POLB | |
| SCHEMBL5253835 | 0.80 | KDM4E (1.00) | KDM4EATMBRD4ALDH1A1POLB | |
| SCHEMBL6528941 | 0.80 | KDM4E (1.00) | KDM4EATMBRD4ALDH1A1POLB | |
| SCHEMBL8694403 | 0.79 | KDM4E (0.60) | KDM4EATMBRD4ALDH1A1POLB | |
| SCHEMBL3231094 | 0.78 | ALDH1A1 (0.52) | KDM4EATMBRD4ALDH1A1POLB | |
| SCHEMBL1305048 | 0.77 | HTR2C (0.57) | KDM4EATMBRD4ALDH1A1POLB | |
| SCHEMBL3239993 | 0.77 | HTR2C (0.57) | KDM4EATMBRD4ALDH1A1POLB | |
| SCHEMBL30415306 | 0.77 | KDM4E (0.83) | KDM4EATMBRD4ALDH1A1POLB | |
| SCHEMBL3256692 | 0.77 | KDM4E (0.83) | KDM4EATMBRD4ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015588-A1 | BENZYL-SUBSTITUTED TETRACYCLIC HETEROCYCLIC COMPOUNDS | NYCOMED GMBH (DE) | 2010-02-11 | — | — | WO | disclosed |