Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3185259 | 1.00 | ALDH1A1 (0.49) | ALDH1A1LMNATRPA1TRPM8EPHX1 | |
| SCHEMBL3185253 | 1.00 | ALDH1A1 (0.49) | ALDH1A1LMNATRPA1TRPM8EPHX1 | |
| Menthol SCHEMBL1599560 | 0.88 | TRPA1 (0.60) | ALDH1A1LMNATRPA1TRPM8EPHX1 | |
| SCHEMBL28792394 | 0.87 | ALDH1A1 (0.50) | ALDH1A1LMNATRPA1TRPM8EPHX1 | |
| SCHEMBL2633946 | 0.83 | ALDH1A1 (0.50) | ALDH1A1LMNATRPA1TRPM8EPHX1 | |
| SCHEMBL96535 | 0.83 | ALDH1A1 (0.50) | ALDH1A1LMNATRPA1TRPM8EPHX1 | |
| SCHEMBL7793167 | 0.82 | ALDH1A1 (0.46) | ALDH1A1LMNATRPA1TRPM8EPHX1 | |
| SCHEMBL16312990 | 0.79 | ALDH1A1 (0.46) | ALDH1A1LMNATRPA1TRPM8EPHX1 | |
| SCHEMBL197029 | 0.79 | ALDH1A1 (0.57) | ALDH1A1LMNATRPA1TRPM8EPHX1 | |
| SCHEMBL14480014 | 0.79 | ALDH1A1 (0.57) | ALDH1A1LMNATRPA1TRPM8EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745438-B2 | 3-(2-acylamino-1-hydroxyethyl)-morpholine derivatives and their use as bace inhibitors | ELI LILLY AND COMPANY (US) | 2010-06-29 | — | — | US | disclosed |
| US-20070225267-A1 | 3-(2-Acylamino-1-Hydroxyethyl)-Morpholine Derivatives and Their Use as Bace Inhibitors | ELI LILLY AND COMPANY | 2007-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225267-A1 | 3-(2-Acylamino-1-Hydroxyethyl)-Morpholine Derivatives and Their Use as Bace Inhibitors | BACE1, BACE2, APP | ALDH1A1 893/4885LMNA 877/4885TRPA1 4096/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.