Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | HTR7 | P34969 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3249183 | 0.95 | MDM2 (0.50) | MDM2TP53ATMHTR7MEN1 | |
| SCHEMBL3247649 | 0.87 | MDM2 (0.53) | MDM2TP53ATMMEN1KMT2A | |
| SCHEMBL3239017 | 0.86 | MDM2 (0.51) | MDM2TP53ATMMEN1KMT2A | |
| SCHEMBL3253003 | 0.83 | MDM2 (0.50) | MDM2TP53ATMSIGMAR1MEN1 | |
| SCHEMBL1320652 | 0.83 | MDM2 (0.54) | MDM2TP53HTR7MEN1KMT2A | |
| SCHEMBL1322368 | 0.80 | MDM2 (0.54) | MDM2TP53HTR7MEN1KMT2A | |
| SCHEMBL3250920 | 0.80 | MDM2 (0.62) | MDM2TP53KMT2A | |
| SCHEMBL1319886 | 0.77 | MDM2 (0.51) | MDM2TP53HTR7MEN1KMT2A | |
| SCHEMBL1322062 | 0.77 | MDM2 (0.54) | MDM2TP53HTR7MEN1KMT2A | |
| SCHEMBL1320368 | 0.76 | MDM2 (0.57) | MDM2TP53HTR7KMT2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066318-B1 | OXINDOLE DERIVATIVES AS ANTICANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2010-05-12 | — | — | EP | claimed |