Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3239223 | 0.95 | MDM2 (0.49) | MDM2TP53ATMHTR1AHTR7 | |
| SCHEMBL3247649 | 0.89 | MDM2 (0.53) | MDM2TP53ATMMEN1KMT2A | |
| SCHEMBL1320652 | 0.87 | MDM2 (0.54) | MDM2TP53HTR1AHTR7MEN1 | |
| SCHEMBL3239017 | 0.87 | MDM2 (0.51) | MDM2TP53ATMMEN1KMT2A | |
| SCHEMBL1322368 | 0.85 | MDM2 (0.54) | MDM2TP53HTR1AHTR7MEN1 | |
| SCHEMBL3253003 | 0.84 | MDM2 (0.50) | MDM2TP53ATMMEN1KMT2A | |
| SCHEMBL3250920 | 0.81 | MDM2 (0.62) | MDM2TP53KMT2A | |
| SCHEMBL1322062 | 0.81 | MDM2 (0.54) | MDM2TP53HTR1AHTR7MEN1 | |
| SCHEMBL1320368 | 0.80 | MDM2 (0.57) | MDM2TP53HTR1AHTR7KMT2A | |
| SCHEMBL1319791 | 0.79 | MDM2 (0.47) | MDM2TP53LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066318-B1 | OXINDOLE DERIVATIVES AS ANTICANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2010-05-12 | — | — | EP | claimed |