Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 6/20 | 0.50 |
| ▸ | TP53 | P04637 | 5/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | CYP51A1 | Q16850 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3239017 | 0.95 | MDM2 (0.51) | MDM2TP53CCR3GAALMNA | |
| SCHEMBL3247649 | 0.87 | MDM2 (0.53) | MDM2TP53CCR3GAALMNA | |
| SCHEMBL3249183 | 0.84 | MDM2 (0.50) | MDM2TP53CCR3LMNAALDH1A1 | |
| SCHEMBL3239223 | 0.83 | MDM2 (0.49) | MDM2TP53ATMMEN1KMT2A | |
| SCHEMBL1321532 | 0.79 | MDM2 (0.48) | MDM2TP53OPRK1ADORA2B | |
| SCHEMBL3250920 | 0.78 | MDM2 (0.62) | MDM2TP53HTTKMT2A | |
| SCHEMBL1319899 | 0.77 | MDM2 (0.53) | MDM2TP53LMNAALDH1A1 | |
| SCHEMBL8199660 | 0.77 | MDM2 (0.49) | MDM2TP53ADORA2BCYP51A1PYGL | |
| SCHEMBL1320417 | 0.76 | MDM2 (0.71) | MDM2TP53HTTSMN1; SMN2 | |
| SCHEMBL1322509 | 0.75 | CYP51A1 (0.51) | MDM2TP53CYP51A1PYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066318-B1 | OXINDOLE DERIVATIVES AS ANTICANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2010-05-12 | — | — | EP | claimed |