Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3239864 | 0.90 | LMNA (0.37) | CNR2LMNAALDH1A1MAPTTP53 | |
| SCHEMBL3246563 | 0.90 | LMNA (0.40) | CNR2LMNAALDH1A1MAPTTP53 | |
| SCHEMBL3241690 | 0.90 | THRB (0.40) | CNR2LMNAMAPTTP53SMN1; SMN2 | |
| SCHEMBL3245011 | 0.88 | LMNA (0.40) | CNR2LMNAALDH1A1MAPTTP53 | |
| SCHEMBL1044730 | 0.87 | LMNA (0.41) | CNR2LMNAALDH1A1MAPTTP53 | |
| SCHEMBL3235095 | 0.87 | CNR2 (0.36) | CNR2LMNAALDH1A1MAPTTP53 | |
| SCHEMBL3243761 | 0.86 | CNR2 (0.37) | CNR2LMNACCR2SMN1; SMN2 | |
| SCHEMBL3239637 | 0.85 | SLC22A12 (0.39) | CNR2LMNAALDH1A1MAPTTP53 | |
| SCHEMBL3245353 | 0.84 | CNR2 (0.41) | CNR2LMNAALDH1A1MAPTTP53 | |
| SCHEMBL3234992 | 0.83 | LMNA (0.38) | LMNAALDH1A1MAPTTP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1564210-B9 | 4-OXOQUINOLINE COMPOUNDS AND UTILIZATION THEREOF AS HIV INTEGRASE INHIBITORS | JAPAN TOBACCO INC (JP) | 2010-03-31 | — | — | EP | claimed |
| EP-1564210-B1 | 4-OXOQUINOLINE COMPOUNDS AND UTILIZATION THEREOF AS HIV INTEGRASE INHIBITORS | JAPAN TOBACCO INC (JP) | 2009-09-16 | — | — | EP | claimed |