SCHEMBL3240761

SCHEMBL3240761

CC(=O)C(=O)CCCCCC(=O)Nc1ccc(C)cc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 7/20 0.71
HDAC2 Q92769 7/20 0.71
HDAC3 O15379 6/20 0.71
HDAC10 Q969S8 6/20 0.71
HDAC11 Q96DB2 5/20 0.71
HDAC8 Q9BY41 5/20 0.71
HDAC6 Q9UBN7 5/20 0.71
NCOR2 Q9Y618 1/20 0.71
HDAC4 P56524 4/20 0.69
HDAC7 Q8WUI4 4/20 0.69
HDAC9 Q9UKV0 4/20 0.69
HDAC5 Q9UQL6 4/20 0.69
ALDH1A1 P00352 3/20 0.62
LMNA P02545 2/20 0.62
POLB P06746 3/20 0.58
TDP1 Q9NUW8 2/20 0.53
NSD2 O96028 1/20 0.53
ABL1 P00519 1/20 0.53
MAPK1 P28482 1/20 0.53
MAPK10 P53779 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL517697 0.88 HDAC3 (0.86) HDAC1HDAC2HDAC3HDAC10HDAC11
SCHEMBL30444771 0.87 HDAC3 (0.76) HDAC1HDAC2HDAC3HDAC10HDAC11
SCHEMBL3228056 0.84 HDAC1 (0.76) HDAC1HDAC2HDAC3HDAC10HDAC11
SCHEMBL13254437 0.83 HDAC3 (0.76) HDAC1HDAC2HDAC3HDAC10HDAC11
SCHEMBL13524769 0.83 HDAC1 (1.00) HDAC1HDAC2HDAC3HDAC10HDAC11
SCHEMBL2319941 0.83 HDAC3 (0.76) HDAC1HDAC2HDAC3HDAC10HDAC11
SCHEMBL5968936 0.83 HDAC3 (0.76) HDAC1HDAC2HDAC3HDAC10HDAC11
SCHEMBL2531377 0.83 HDAC3 (0.76) HDAC1HDAC2HDAC3HDAC10HDAC11
SCHEMBL17252159 0.83 HDAC3 (0.76) HDAC1HDAC2HDAC3HDAC10HDAC11
SCHEMBL1064449 0.83 HDAC1 (0.76) HDAC1HDAC2HDAC3HDAC10HDAC11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010028193-A1 COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS REPLIGEN CORPORATION (US) 2010-03-11 WO claimed
WO-2010028193-A1 COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS REPLIGEN CORPORATION (US) 2010-03-11 WO disclosed
WO-2010028193-A1 COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS REPLIGEN CORPORATION (US) 2010-03-11 WO disclosed