Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.76 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.76 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.76 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.76 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.76 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.76 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.76 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.76 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.76 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.76 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.76 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | NSD2 | O96028 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2704165 | 0.86 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC10HDAC11 | |
| SCHEMBL517697 | 0.85 | HDAC3 (0.86) | HDAC1HDAC2HDAC3HDAC10HDAC11 | |
| SCHEMBL3240761 | 0.84 | HDAC1 (0.71) | HDAC1HDAC2HDAC3HDAC10HDAC11 | |
| SCHEMBL7367523 | 0.83 | ALDH1A1 (0.54) | HDAC1HDAC2HDAC3HDAC10HDAC11 | |
| SCHEMBL7373775 | 0.83 | HDAC1 (0.68) | HDAC1HDAC2HDAC3HDAC10HDAC11 | |
| SCHEMBL7369022 | 0.81 | HDAC1 (0.80) | HDAC1HDAC2HDAC3HDAC10HDAC11 | |
| SCHEMBL13254437 | 0.81 | HDAC3 (0.76) | HDAC1HDAC2HDAC3HDAC10HDAC11 | |
| SCHEMBL2319941 | 0.81 | HDAC3 (0.76) | HDAC1HDAC2HDAC3HDAC10HDAC11 | |
| SCHEMBL13524769 | 0.81 | HDAC1 (1.00) | HDAC1HDAC2HDAC3HDAC10HDAC11 | |
| SCHEMBL2531377 | 0.81 | HDAC3 (0.76) | HDAC1HDAC2HDAC3HDAC10HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |