Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.36 |
| ▸ | DRD3 | P35462 | 7/20 | 0.36 |
| ▸ | DRD4 | P21917 | 5/20 | 0.36 |
| ▸ | DRD1 | P21728 | 3/20 | 0.36 |
| ▸ | DRD5 | P21918 | 3/20 | 0.36 |
| ▸ | HTR1D | P28221 | 2/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30665126 | 0.86 | DRD2 (0.42) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL2984151 | 0.86 | DRD2 (0.42) | DRD2DRD3DRD4DRD1DRD5 | |
| Hydrogen Sulfide SCHEMBL28795253 | 0.84 | DRD2 (0.41) | DRD2DRD3DRD4DRD1DRD5 | |
| Biphenyl SCHEMBL4350539 | 0.80 | DRD2 (0.39) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL23301867 | 0.78 | DRD2 (0.40) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL6934553 | 0.76 | MAPT (0.43) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL1712875 | 0.76 | DRD2 (0.43) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL31195545 | 0.75 | MRGPRX4 (0.40) | DRD2DRD3DRD4DRD1DRD5 | |
| Hydrogen Sulfide SCHEMBL27838727 | 0.75 | MAPT (0.42) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL19948194 | 0.73 | DRD2 (0.41) | DRD2DRD3DRD4DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209774-A1 | PYRIMIDINEDIONE DERIVATIVES | Concert Pharmaceuticals Inc. (US) | 2010-07-28 | — | — | EP | disclosed |
| WO-2009045476-A1 | PYRIMIDINEDIONE DERIVATIVES | CONCERT PHARMACEUTICALS, INC. (US) | 2009-04-09 | — | — | WO | disclosed |