Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1C | Q14123 | 4/20 | 0.59 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3002847 | 0.89 | PDE1C (0.54) | PDE1CCYP3A4CYP2C9CYP2C19KDM4E | |
| SCHEMBL3004824 | 0.87 | PDE1C (0.69) | PDE1CCACNA1BPOLBCYP3A4CYP2C9 | |
| SCHEMBL4258159 | 0.83 | PDE1C (0.57) | PDE1CCACNA1BPOLBCYP3A4CYP2C9 | |
| SCHEMBL3242915 | 0.81 | PDE1C (0.48) | PDE1CMEN1KMT2AGPBAR1 | |
| SCHEMBL4260613 | 0.80 | ADORA2B (0.57) | PDE1CPOLBKDM4EALDH1A1MEN1 | |
| SCHEMBL3237974 | 0.79 | TSHR (0.44) | PDE1CCACNA1BMAPTTSHR | |
| SCHEMBL2996950 | 0.79 | PDE1C (0.45) | PDE1CGAATSHR | |
| SCHEMBL4260307 | 0.79 | PDE1C (0.36) | PDE1CCACNA1BPOLB | |
| SCHEMBL3000827 | 0.78 | PDE1C (0.45) | PDE1CALDH1A1 | |
| SCHEMBL3006899 | 0.77 | PDE1C (0.44) | PDE1CKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002483-A1 | OPTIONALLY CONDENSED DIHYDRO PYRIDINE, DIHYDROPYRIMIDINE AND DIHYDRO PYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |