Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1C | Q14123 | 3/20 | 0.57 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | BRD2 | P25440 | 1/20 | 0.46 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.46 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3004824 | 0.87 | PDE1C (0.69) | PDE1CCACNA1BPOLBCYP3A4CYP2C9 | |
| SCHEMBL3241017 | 0.83 | PDE1C (0.59) | PDE1CCACNA1BPOLBCYP3A4CYP2C9 | |
| SCHEMBL2999858 | 0.75 | KDM4E (0.65) | CACNA1BPOLBCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL10830286 | 0.74 | PDE1C (0.70) | PDE1CCACNA1BKDM4EALDH1A1TSHR | |
| SCHEMBL3248414 | 0.72 | MAPT (0.57) | CYP3A4CYP2C9CYP2C19KDM4EALDH1A1 | |
| SCHEMBL11824598 | 0.71 | ADORA3 (0.73) | PDE1CPOLBCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL13088047 | 0.71 | PDE1C (0.61) | PDE1CCACNA1BKDM4EALDH1A1GAA | |
| SCHEMBL3010323 | 0.71 | MAPT (0.43) | PDE1CCACNA1BMAPTBRD4BRD2 | |
| SCHEMBL3247037 | 0.70 | ALDH1A1 (0.71) | PDE1CPOLBALDH1A1GAAMAPT | |
| SCHEMBL3059809 | 0.70 | GAA (0.73) | PDE1CCACNA1BKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009006580-A1 | OPTIONALLY CONDENSED DIHYDROPYRIDINE, DIHYDROPYRIMIDINE AND DIHYDROPYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2009-01-08 | — | — | WO | disclosed |