Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3241379 | 0.87 | CHRM1 (0.47) | CHRM1LMNATP53 | |
| SCHEMBL31653939 | 0.78 | CHRM1 (1.00) | CHRM1LMNA | |
| SCHEMBL1549479 | 0.78 | CHRM1 (1.00) | CHRM1LMNA | |
| SCHEMBL13762897 | 0.77 | CHRM1 (0.77) | CHRM1LMNATP53 | |
| SCHEMBL3236188 | 0.77 | CHRM1 (0.69) | CHRM1LMNATP53 | |
| SCHEMBL9028399 | 0.76 | LMNA (1.00) | CHRM1LMNATP53 | |
| SCHEMBL31554247 | 0.76 | LMNA (1.00) | CHRM1LMNATP53 | |
| SCHEMBL17338644 | 0.76 | LMNA (0.69) | CHRM1LMNATP53 | |
| SCHEMBL2487853 | 0.75 | CHRM1 (0.93) | CHRM1LMNA | |
| SCHEMBL1661468 | 0.75 | LMNA (0.71) | CHRM1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |
| CN-101321733-A | Quinolone M1 receptor positive allosteric modulators | MERCK SHARP & DOHME (US) | 2008-12-10 | — | — | CN | claimed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | disclosed |
| CN-101321733-A | Quinolone M1 receptor positive allosteric modulators | MERCK SHARP & DOHME (US) | 2008-12-10 | — | — | CN | disclosed |