Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | BUB1 | O43683 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3241022 | 0.87 | CHRM1 (0.64) | CHRM1LMNATP53 | |
| SCHEMBL3236193 | 0.79 | CHRM1 (0.53) | CHRM1LMNATP53MAPT | |
| SCHEMBL10863325 | 0.77 | NR4A2 (0.52) | CHRM1LMNATP53 | |
| SCHEMBL2491002 | 0.76 | CHRM1 (0.71) | CHRM1LMNAMAPT | |
| SCHEMBL3241260 | 0.76 | TP53 (0.68) | CHRM1LMNATP53MAPT | |
| SCHEMBL3237179 | 0.75 | LMNA (0.59) | CHRM1LMNATP53 | |
| SCHEMBL3234156 | 0.75 | LMNA (0.62) | CHRM1LMNATP53 | |
| SCHEMBL2490511 | 0.75 | LMNA (0.59) | CHRM1LMNATP53 | |
| SCHEMBL2487940 | 0.73 | CHRM1 (0.44) | CHRM1LMNATP53MAPT | |
| SCHEMBL2489082 | 0.73 | CHRM1 (0.45) | CHRM1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |