Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.82 |
| ▸ | RET | P07949 | 5/20 | 0.82 |
| ▸ | SRC | P12931 | 3/20 | 0.82 |
| ▸ | RAF1 | P04049 | 5/20 | 0.74 |
| ▸ | BRAF | P15056 | 4/20 | 0.74 |
| ▸ | KIF5B | P33176 | 2/20 | 0.69 |
| ▸ | EPHB2 | P29323 | 2/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.69 |
| ▸ | FLT1 | P17948 | 1/20 | 0.69 |
| ▸ | CDK2 | P24941 | 1/20 | 0.69 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.69 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.69 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.67 |
| ▸ | EGFR | P00533 | 8/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.66 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.66 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.66 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.66 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.66 |
| ▸ | LTK | P29376 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5474772 | 0.90 | KDR (1.00) | KDRRETSRCRAF1KIF5B | |
| Hydrochloric Acid SCHEMBL5483854 | 0.89 | KDR (0.97) | KDRRETSRCRAF1KIF5B | |
| SCHEMBL2102382 | 0.88 | EGFR (0.82) | KDRRETSRCRAF1BRAF | |
| SCHEMBL5239599 | 0.88 | EGFR (0.80) | KDRRETRAF1BRAFKIF5B | |
| SCHEMBL14996742 | 0.87 | EGFR (0.82) | KDRRETSRCRAF1BRAF | |
| SCHEMBL4229994 | 0.87 | EGFR (0.82) | KDRRETSRCKIF5BEPHB2 | |
| SCHEMBL15052373 | 0.85 | BRAF (1.00) | RAF1BRAF | |
| SCHEMBL3239025 | 0.84 | EGFR (0.66) | KDRRETSRCRAF1BRAF | |
| SCHEMBL644810 | 0.84 | EGFR (0.83) | KDRRETSRCRAF1BRAF | |
| SCHEMBL13604745 | 0.84 | EGFR (0.82) | KDRRETRAF1BRAFKIF5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1369418-B1 | QUINAZOLINE DERIVATIVES | MITSUBISHI TANABE PHARMA CORP (JP) | 2010-07-28 | — | — | EP | disclosed |
| US-20070265260-A1 | Quinazoline derivatives | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2007-11-15 | — | — | US | disclosed |
| US-7294629-B2 | Quinazoline derivatives | MITSUBISHI PHARMA CORPORATION (JP) | 2007-11-13 | — | — | US | disclosed |
| US-20040116422-A1 | Quinazoline derivatives | MITSUBISHI PHARMA CORPORATION (JP) | 2004-06-17 | — | — | US | disclosed |
| EP-1369418-A1 | QUINAZOLINE DERIVATIVES | Mitsubishi Pharma Corporation (JP) | 2003-12-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265260-A1 | Quinazoline derivatives | TYK2, ROR1, JAK1 | KDR 704/4885RET 219/4885SRC 161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.