Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.82 |
| ▸ | KDR | P35968 | 6/20 | 0.82 |
| ▸ | RET | P07949 | 6/20 | 0.82 |
| ▸ | LCK | P06239 | 3/20 | 0.80 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.77 |
| ▸ | AURKA | O14965 | 2/20 | 0.77 |
| ▸ | RAF1 | P04049 | 1/20 | 0.74 |
| ▸ | BRAF | P15056 | 1/20 | 0.74 |
| ▸ | KIF5B | P33176 | 3/20 | 0.70 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.70 |
| ▸ | GAK | O14976 | 1/20 | 0.70 |
| ▸ | STK10 | O94804 | 1/20 | 0.70 |
| ▸ | FLT3 | P36888 | 1/20 | 0.70 |
| ▸ | JAK3 | P52333 | 1/20 | 0.70 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.70 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.70 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.70 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.70 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.70 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5239599 | 0.96 | EGFR (0.80) | EGFRKDRRETLCKAURKB | |
| SCHEMBL29515328 | 0.90 | EGFR (1.00) | EGFRKDRRETLCKKIF5B | |
| SCHEMBL1257431 | 0.90 | EGFR (1.00) | EGFRKDRRETLCKKIF5B | |
| SCHEMBL20792806 | 0.89 | EGFR (0.87) | EGFRKDRRETLCKAURKB | |
| Hydrochloric Acid SCHEMBL5475737 | 0.89 | EGFR (1.00) | EGFRKDRRETLCKRIPK2 | |
| SCHEMBL6674055 | 0.89 | KDR (0.82) | EGFRKDRRETLCKAURKB | |
| SCHEMBL2100551 | 0.89 | EGFR (0.82) | EGFRKDRRETLCKAURKB | |
| SCHEMBL6675906 | 0.88 | KDR (0.73) | EGFRKDRRETLCKAURKB | |
| SCHEMBL14159636 | 0.88 | KDR (0.73) | EGFRKDRRETLCKAURKB | |
| SCHEMBL10101988 | 0.88 | EGFR (0.82) | EGFRKDRRETLCKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312343-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | HENNEQUIN LAURENT FRANCOIS AND | 2009-12-17 | — | — | US | disclosed |
| US-7569577-B2 | Quinazoline derivatives as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2009-08-04 | — | — | US | disclosed |
| US-20070043009-A1 | Quinazoline derivatives as tyrosine kinase inhibitors | ASTRAZENECA AB (SE) | 2007-02-22 | — | — | US | disclosed |
| US-20070032513-A1 | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312343-A1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS | ERBB2, ABL1, EGFR | EGFR 3/4885KDR 225/4885RET 51/4885 |
| US-20070032513-A1 | Quinazoline derivatives | ERBB2, EGFR, ABL1 | EGFR 2/4885KDR 124/4885RET 56/4885 |
| US-20070043009-A1 | Quinazoline derivatives as tyrosine kinase inhibitors | ERBB2, ABL1, EGFR | EGFR 3/4885KDR 180/4885RET 30/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.