Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 15/20 | 0.74 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3234856 | 0.87 | IMPDH2 (0.79) | IMPDH2MAOAKIF11PLK4CHEK1 | |
| SCHEMBL13271345 | 0.85 | IMPDH2 (0.76) | IMPDH2MAOAKIF11PLK4CHEK1 | |
| SCHEMBL3237650 | 0.82 | IMPDH2 (0.71) | IMPDH2MAOAKIF11PLK4CHEK1 | |
| SCHEMBL14375551 | 0.81 | IMPDH2 (1.00) | IMPDH2MAOAKIF11 | |
| SCHEMBL14376025 | 0.81 | IMPDH2 (0.77) | IMPDH2MAOAKIF11PLK4CHEK1 | |
| SCHEMBL14376114 | 0.81 | IMPDH2 (0.65) | IMPDH2MAOAKIF11PLK4CHEK1 | |
| SCHEMBL3233953 | 0.80 | IMPDH2 (0.68) | IMPDH2MAOAKIF11PLK4CHEK1 | |
| SCHEMBL14376232 | 0.79 | IMPDH2 (0.61) | IMPDH2MAOAKIF11KDM4EALDH1A1 | |
| SCHEMBL3241716 | 0.78 | IMPDH2 (0.65) | IMPDH2MAOAKIF11KDRGAA | |
| SCHEMBL14375555 | 0.78 | IMPDH2 (0.72) | IMPDH2KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458392-B9 | ACRIDONES AS INHIBITORS OF IMPDH ENZYME | BRISTOL MYERS SQUIBB CO (US) | 2010-07-28 | — | — | EP | disclosed |
| EP-1458392-B1 | ACRIDONES AS INHIBITORS OF IMPDH ENZYME | BRISTOL MYERS SQUIBB CO (US) | 2009-09-02 | — | — | EP | disclosed |
| US-7312209-B2 | Acridone inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-25 | — | — | US | disclosed |