Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 8/20 | 0.61 |
| ▸ | KIF11 | P52732 | 1/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13271380 | 0.83 | MAOA (0.67) | IMPDH2KIF11MAOAGAAKDM4E | |
| SCHEMBL3234597 | 0.81 | PARP1 (0.67) | IMPDH2KIF11MAOAGAAKDM4E | |
| SCHEMBL6210190 | 0.80 | IMPDH2 (0.62) | IMPDH2KIF11MAOAGAAKDM4E | |
| SCHEMBL30571577 | 0.79 | KIF11 (0.86) | IMPDH2KIF11MAOAGAAKDM4E | |
| SCHEMBL14376207 | 0.79 | KIF11 (0.86) | IMPDH2KIF11MAOAGAAKDM4E | |
| SCHEMBL3241591 | 0.79 | IMPDH2 (0.74) | IMPDH2KIF11MAOAGAAKDM4E | |
| SCHEMBL3205039 | 0.76 | TLR8 (0.53) | KIF11KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL14349303 | 0.76 | KIF11 (0.62) | IMPDH2KIF11MAOAGAAKDM4E | |
| SCHEMBL13271150 | 0.76 | KDM4E (0.73) | IMPDH2KIF11MAOAGAAKDM4E | |
| SCHEMBL16135413 | 0.76 | IMPDH2 (0.57) | IMPDH2KIF11MAOAGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312209-B2 | Acridone inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-25 | — | — | US | disclosed |