Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | F3 | P13726 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.32 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3244477 | 0.85 | DAO (0.44) | CYP1A2HSD17B10MCL1BCL2A1CSNK2A2 | |
| SCHEMBL13928207 | 0.85 | GABRA1 (0.43) | CYP1A2HSD17B10KDM4EALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL3251797 | 0.84 | GABRA1 (0.43) | CYP1A2HSD17B10KDM4EALDH1A1MAPT | |
| SCHEMBL3250776 | 0.82 | PLA2G1B (0.41) | CYP1A2HSD17B10MCL1F7F3 | |
| SCHEMBL3251438 | 0.81 | IDO1 (0.37) | CYP1A2HSD17B10HTTPARP1 | |
| Hydrochloric Acid SCHEMBL4164363 | 0.81 | CYP2C19 (0.42) | CYP1A2HSD17B10HTR7PARP1MAPT | |
| SCHEMBL3241773 | 0.80 | NGFR (0.49) | CYP1A2HSD17B10MCL1F7F3 | |
| SCHEMBL3249253 | 0.80 | PLA2G1B (0.37) | CYP1A2HSD17B10MCL1F7F3 | |
| SCHEMBL3253510 | 0.78 | MAOA (0.39) | CYP1A2HSD17B10F7F3KDM4E | |
| SCHEMBL3243089 | 0.78 | CYP1A2 (0.45) | CYP1A2HSD17B10F7F3CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |