Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7925289 | 0.85 | USP2 (0.68) | USP2HDAC3HDAC1POLBMAPT | |
| SCHEMBL7940673 | 0.80 | USP2 (0.52) | USP2MAPK1TP53ALOX15CASP1 | |
| SCHEMBL17009233 | 0.77 | USP2 (0.85) | USP2MAPK1TP53ALOX15CASP1 | |
| SCHEMBL7694996 | 0.77 | USP2 (0.85) | USP2MAPK1TP53ALOX15CASP1 | |
| SCHEMBL3238234 | 0.76 | HDAC1 (0.70) | HDAC3HDAC1HDAC2NCOR2HDAC4 | |
| SCHEMBL17009271 | 0.76 | USP2 (0.88) | USP2MAPK1TP53ALOX15CASP1 | |
| SCHEMBL3240756 | 0.76 | HDAC3 (0.59) | USP2HDAC3HDAC1MAPK1TP53 | |
| SCHEMBL13438260 | 0.75 | USP2 (0.93) | USP2MAPK1TP53ALOX15CASP1 | |
| SCHEMBL12472765 | 0.74 | KDM4E (0.48) | USP2MAPK1MEN1KMT2APOLB | |
| SCHEMBL9784530 | 0.73 | USP2 (0.82) | USP2MAPK1TP53ALOX15CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |